Primary hyperparathyroidism and coexisting nephrogenic diabetes insipidus: rapid postoperative correction.

Title

Primary hyperparathyroidism and coexisting nephrogenic diabetes insipidus: rapid postoperative correction.

Creator

Ellis G; Spirtos G; Polsky F

Publisher

Southern medical journal

Date

1991
1991-08

Description

Shortly after diagnosis of primary hyperparathyroidism, a patient had serum hyperosmolality, polyuria, isosthenuria, profound potassium depletion, and elevated plasma antidiuretic hormone levels, all consistent with nephrogenic diabetes insipidus. After parathyroidectomy, serum calcium and serum osmolality levels fell concurrently. Profound potassium deficits did not recur. We propose that (1) hypercalcemia produced a concentrating defect and polyuria; (2) renal tubular acidosis and polyuria combined to produce severe potassium depletion; (3) hypokalemia potentiated the nephrogenic diabetes insipidus caused by hypercalcemia; and (4) postoperative disappearance of the diabetes insipidus confirmed its reversible, purely metabolic causes.

Subject

Diabetes Insipidus/*complications/etiology; Humans; Hypercalcemia/complications; Hyperparathyroidism/*complications/surgery; Hypokalemia/complications; Male; Middle Aged

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1019–1022

Issue

8

Volume

84

Citation

Ellis G; Spirtos G; Polsky F, “Primary hyperparathyroidism and coexisting nephrogenic diabetes insipidus: rapid postoperative correction.,” NEOMED Bibliography Database, accessed January 23, 2022, https://neomed.omeka.net/items/show/4268.

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