Ischemic colitis revisited: a prospective study identifying hypercoagulability as a risk factor.

Title

Ischemic colitis revisited: a prospective study identifying hypercoagulability as a risk factor.

Creator

Midian-Singh Robin; Polen Ann; Durishin Catherine; Crock Ronald D; Whittier Frederick C; Fahmy Nabil

Publisher

Southern medical journal

Date

2004
2004-02

Description

BACKGROUND: Although causes for ischemic colitis have been identified, many cases are deemed idiopathic. Some reports suggest an association between ischemic colitis and coagulation disorders. Our purpose was to explore the relationship of ischemic colitis and clotting abnormalities. METHODS: Eighteen patients consented to undergo a hypercoagulability evaluation. Tests included protein C, protein S, activated protein C resistance, factor V Leiden, anticardiolipin antibodies, antineutrophil cytoplasmic antibodies, rheumatoid factor, antithrombin III, anti-smooth muscle antibody, lupus anticoagulant panel, and prothrombin 20210G/A mutation (in women undergoing hormone replacement therapy). RESULTS: Five of 18 patients tested positive for coagulation abnormalities, including factor V and activated protein C resistance, protein S deficiency, prothrombin 20210G/A mutation, and anticardiolipin antibody. CONCLUSION: To our knowledge, this is the largest series of patients with ischemic colitis studied for coagulation defects in the United States. The prevalence of clotting disorders in our study (28%) was higher than that in the general population (8.4%). Coagulation disorders should be considered in some cases of ischemic colitis that are thought to be idiopathic.

Subject

80 and over; Aged; Blood Coagulation Disorders/*complications; Colitis; Female; Humans; Ischemic/blood/epidemiology/*etiology; Male; Middle Aged; Prevalence; Prospective Studies; Risk Factors; United States/epidemiology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

120–123

Issue

2

Volume

97

Citation

Midian-Singh Robin; Polen Ann; Durishin Catherine; Crock Ronald D; Whittier Frederick C; Fahmy Nabil, “Ischemic colitis revisited: a prospective study identifying hypercoagulability as a risk factor.,” NEOMED Bibliography Database, accessed May 7, 2021, https://neomed.omeka.net/items/show/4310.

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