Central visual pathways in glaucoma: evidence for distal mechanisms of neuronal self-repair.

Title

Central visual pathways in glaucoma: evidence for distal mechanisms of neuronal self-repair.

Creator

Crish Samuel D; Calkins David J

Publisher

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

Date

2015
2015-09

Description

As in other age-related neurodegenerative diseases, progression of neurodegeneration in glaucoma involves early axonopathy. In glaucoma, this is marked by degradation of active transport along retinal ganglion cell (RGC) axons projecting from the retina to the brain. In experimental systems, transport degradation occurs first in the most distal site in the RGC projection, the superior colliculus (SC) of the midbrain. Even as degradation progresses from one retinotopic sector to the next, important structures in the affected sectors persist, including synapses from RGC axon terminals onto SC neurons. This structural persistence is accompanied by focally increased brain-derived neurotrophic factor in hypertrophic SC astrocyte glia and defines a therapeutic window of opportunity. Thus, central brain structures in glaucoma may respond to disease-relevant stress by induction of mechanisms useful for maintaining retinal signals.

Subject

Glaucoma/*pathology/*physiopathology; Humans; Neurons/*physiology; Recovery of Function/*physiology; Visual Pathways/*physiopathology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

S29–37

Volume

35 Suppl 1

Citation

Crish Samuel D; Calkins David J, “Central visual pathways in glaucoma: evidence for distal mechanisms of neuronal self-repair.,” NEOMED Bibliography Database, accessed June 27, 2022, https://neomed.omeka.net/items/show/4427.

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