Long-term potentiation induces synaptic plasticity at nontetanized adjacent synapses.

Long-term potentiation induces synaptic plasticity at nontetanized adjacent synapses.

Coussens C M; Teyler T J

Learning & memory (Cold Spring Harbor, N.Y.)

1996

1996-10

The two forms of long-term potentiation (LTP) and one form of long-term depression (LTD) in hippocampal area CA1 are induced by different afferent tetani: LTD is induced by a 3- to 5-Hz tetanus, whereas higher frequencies are necessary for LTP mediated by NMDA receptors (25- to 50-Hz tetanus) and LTP mediated by voltage-dependent calcium channels (200-Hz tetanus). It has been suggested that the three forms are induced by graded increases in postsynaptic calcium, with LTD being induced at the lowest calcium concentration. We hypothesized that synapses near a site of LTP induction would elicit LTD owing to diffusion of calcium or its binding proteins. This was tested using a fixed multistimulating electrode array spanning stratum radiatum in area CA1 of rat hippocampal slices. The tetanized sites all displayed LTP. Nontetanized sites displayed LTD following a 50-Hz tetanus, whereas LTD was often seen following a

Action Potentials/physiology; Animals; Electric Stimulation/methods; Excitatory Postsynaptic Potentials/physiology; In Vitro Techniques; Long-Evans; Long-Term Potentiation/*physiology; Neuronal Plasticity/*physiology; Rats; Synapses/*physiology

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106–114

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