Thrombopoietic status of patients on haemodialysis.

Title

Thrombopoietic status of patients on haemodialysis.

Creator

Bat Taha; Bat Betul E; El-Moghraby Ahmed; Patel Samir; Feng Xingmin; Dunbar Cynthia E; Sarac Erdal

Publisher

British journal of haematology

Date

2016
2016-03

Description

Thrombocytopenia is a potential dialysis-related treatment complication. Developments in bio-compatible dialyser membranes have decreased the occurrence of thrombocytopenia. We investigated whether thrombopoiesis is impaired in haemodialysis patients by measuring the thrombopoietin level and absolute immature platelet number (AIPN) in the blood of patients undergoing haemodialysis. Samples were collected from the dialysis tubing pre- and post- haemodialysis in a cohort of 45 well-characterized haemodialysis patients. Thrombopoietin levels and AIPN increased following haemodialysis, despite no change in platelet count. Observed increase in release of immature platelets from the bone marrow following haemodialysis indicates possible complement activation secondary to interaction between blood constituents and the dialysis membrane.

Subject

80 and over; absolute immature platelet number; Adult; Aged; Chronic/blood/therapy; Female; haemodialysis; Humans; IL1A (IL1alpha); immature platelet fraction; Kidney Failure; Male; Middle Aged; Platelet Count; Platelet Function Tests/methods; Renal Dialysis/*adverse effects; Thrombocytopenia/blood/*etiology; Thrombopoiesis/*physiology; thrombopoietin; Thrombopoietin/blood

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

954–957

Issue

6

Volume

172

Citation

Bat Taha; Bat Betul E; El-Moghraby Ahmed; Patel Samir; Feng Xingmin; Dunbar Cynthia E; Sarac Erdal, “Thrombopoietic status of patients on haemodialysis.,” NEOMED Bibliography Database, accessed July 27, 2021, https://neomed.omeka.net/items/show/4442.

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