Sex differences in K+-evoked striatal dopamine output from superfused striatal tissue fragments of reserpine-treated CD-1 mice.

Title

Sex differences in K+-evoked striatal dopamine output from superfused striatal tissue fragments of reserpine-treated CD-1 mice.

Creator

Ji J; McDermott J L; Dluzen D E

Publisher

Journal of neuroendocrinology

Date

2007
2007-09

Description

Reserpine inhibits vesicular monoamine transporter-2 (VMAT-2) function and thereby impairs vesicular dopamine (DA) storage within nerve terminals. The present report compared the effects of reserpine treatment upon the striatal dopaminergic system in male and female mice as a means to assess potential sex differences in VMAT-2/DA storage function. After treatment with reserpine, male mice showed significantly greater striatal DA concentrations and K+ -evoked DA output from the striatum compared to females. By contrast, no statistically significant sex differences were observed in methamphetamine-evoked DA output in reserpine-treated mice. These results demonstrate a clear sex difference in the striatal dopaminergic responses to reserpine and suggest that females possess a more active VMAT-2/DA storage capacity, as indicated by the greater degree of deficits observed when VMAT-2/DA storage function is inhibited by reserpine. Such findings have important implications for understanding some of the bases for sex differences in neurotoxicity and neurodegeneration of the nigrostriatal dopaminergic system.

Subject

Adrenergic Uptake Inhibitors/*metabolism; Animals; Corpus Striatum/anatomy & histology/*metabolism; Dopamine Agents/metabolism; Dopamine/*metabolism; Female; Male; Methamphetamine/metabolism; Mice; Potassium/*metabolism; Reserpine/*metabolism; Sex Factors; Tissue Culture Techniques; Vesicular Monoamine Transport Proteins/metabolism

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

725–731

Issue

9

Volume

19

Citation

Ji J; McDermott J L; Dluzen D E, “Sex differences in K+-evoked striatal dopamine output from superfused striatal tissue fragments of reserpine-treated CD-1 mice.,” NEOMED Bibliography Database, accessed May 14, 2021, https://neomed.omeka.net/items/show/4448.

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