Estrogen, anti-estrogen, and gender: differences in methamphetamine neurotoxicity.

Estrogen, anti-estrogen, and gender: differences in methamphetamine neurotoxicity.

Dluzen Dean E; McDermott Janet L

Annals of the New York Academy of Sciences

2002

2002-06

In Part 1 of this report, we review data on the effects of estrogen (E), the anti-E tamoxifen (TMX), and testosterone (T) on methamphetamine (METH)-induced neurotoxicity in female and male CD-1 mice. Treatment of gonadectomized females with a physiological regimen of E significantly diminished the amount of striatal dopamine (DA) depletion to METH compared with non-E-treated mice. If these

*Neurotoxins; *Sex Characteristics; Animals; Biological; Estrogen Antagonists/*pharmacology; Estrogens/*physiology; Female; Humans; Male; Methamphetamine/*toxicity; Mice; Models; Tamoxifen/pharmacology; Testosterone/pharmacology

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

136–156

965