J-LEAPS peptide and LEAPS dendritic cell vaccines.

J-LEAPS peptide and LEAPS dendritic cell vaccines.

Rosenthal Ken S; Taylor Patricia; Zimmerman Daniel H

Microbial biotechnology

2012

2012-03

The J-LEAPS vaccines contain a peptide from beta-2-microglobulin covalently attached to disease-related peptides of 8-30 amino acids which contain a T cell epitope. The J-LEAPS vaccines can initiate a protective Th1 immune response or modulate an ongoing Th17 autoimmune response to the peptide. J-LEAPS vaccines activate and direct the nature of the subsequent immune response by promoting the maturation of precursor cells into a unique type of dendritic cell that produces interleukin 12, but not IL-1 or tumour necrosis factor, and presents the antigenic peptide to T cells. Adoptive transfer of JgD-LEAPS dendritic cells, matured with an anti-HSV-1 vaccine, promoted antigen-specific Th1 protection against lethal challenge with the virus. J-LEAPS peptide immunogens and J-LEAPS dendritic cell vaccines have potential applications for antimicrobial prevention and therapy, treatment of autoimmune diseases, and for cancer immunotherapy.

Antigens/genetics/*immunology; Autoimmune Diseases/therapy; beta 2-Microglobulin/genetics/*immunology; Communicable Disease Control/methods; Dendritic Cells/*immunology; Humans; Immunotherapy/*methods; Neoplasms/therapy; Recombinant Fusion Proteins/genetics/immunology

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

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