Coronary microvascular Kv1 channels as regulatory sensors of intracellular pyridine nucleotide redox potential.

Title

Coronary microvascular Kv1 channels as regulatory sensors of intracellular pyridine nucleotide redox potential.

Creator

Dwenger Marc M; Ohanyan Vahagn; Navedo Manuel F; Nystoriak Matthew A

Publisher

Microcirculation (New York, N.Y. : 1994)

Date

2018
2018-01

Description

Smooth muscle voltage-gated potassium (Kv) channels are important regulators of microvascular tone and tissue perfusion. Recent studies indicate that Kv1 channels represent a key component of the physiological coupling between coronary blood flow and myocardial oxygen demand. While the mechanisms by which metabolic changes in the heart are transduced to alter coronary Kv1 channel gating and promote vasodilation are unclear, a growing body of evidence underscores a pivotal role of Kv1 channels in sensing the cellular redox status. Here, we discuss current knowledge of mechanisms of Kv channel redox regulation with respect to pyridine nucleotide modulation of Kv1 function via ancillary Kvbeta proteins as well as direct modulation of channel activity via reactive oxygen and nitrogen species. We identify areas of additional research to address the integration of regulatory processes under altered physiological and pathophysiological conditions that may reveal insights into novel treatment strategies for conditions in which the matching of coronary blood supply and myocardial oxygen demand is compromised.

Subject

* NADH; *endothelium; *ion channels; *vascular smooth muscle; *vasodilation; Animals; Coronary Vessels/chemistry; Humans; Microcirculation; Oxidation-Reduction; Potassium Channels; Pyrimidine Nucleotides/*metabolism; Reactive Nitrogen Species/metabolism; Reactive Oxygen Species/metabolism; Voltage-Gated/*physiology

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Issue

1

Volume

25

Citation

Dwenger Marc M; Ohanyan Vahagn; Navedo Manuel F; Nystoriak Matthew A, “Coronary microvascular Kv1 channels as regulatory sensors of intracellular pyridine nucleotide redox potential.,” NEOMED Bibliography Database, accessed January 18, 2021, https://neomed.omeka.net/items/show/4504.

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