Circadian variation in cell-adhesion molecule expression by normal human leukocytes.

Title

Circadian variation in cell-adhesion molecule expression by normal human leukocytes.

Creator

Niehaus Gary D; Ervin Elyce; Patel Amit; Khanna Kamal; Vanek Vincent W; Fagan Diana L

Publisher

Canadian journal of physiology and pharmacology

Date

2002
2002-10

Description

Adhesion molecules located on the surface of blood-borne leukocytes permit adherence of leukocytes to the microvascular endothelium, diapedesis of leukocytes across vessel walls, formation of intimate multicell interactions, and enhanced transmembrane signal transduction. Since some leukocyte-mediated immune functions exhibit nocturnal intensification, the current study was conducted to investigate the hypothesis that expression of selected cell adhesion molecules (CAM) varies with circadian periodicity. Blood was collected from normal human donors over a 24-h period and CAM expression by monocytes, neutrophils, and lymphocytes evaluated by monoclonal antibody binding and flow cytometry. All leukocyte classes exhibited significant circadian-like variation (p \textless 0.05) in CD62L (L-selectin) expression. Similarly, a diurnal variation (p \textless 0.05) in monocyte and neutrophil CD54 (ICAM-1) was observed. Finally, neutrophils demonstrated a circadian-like variation (p \textless 0.05) in CD11a (LFA-1a). The rhythmic alterations in CAM expression may be clinically relevant, since changes in CAM expression have the potential to modulate the leukocyte-induced pathogenesis associated with disease progressions such as nocturnal asthma, the nighttime exacerbations of rheumatoid arthritis, and the high nocturnal incidence of cerebrovascular and cardiovascular crisis.

Subject

*Circadian Rhythm; Adult; CD11a Antigen/metabolism; CD11b Antigen/metabolism; Cell Adhesion Molecules/*metabolism; Female; Flow Cytometry; Humans; Integrin alpha Chains/metabolism; Intercellular Adhesion Molecule-1/metabolism; L-Selectin/metabolism; Leukocytes/*metabolism; Lymphocytes/metabolism; Male; Middle Aged; Monocytes/metabolism; Neutrophils/metabolism

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

935–940

Issue

10

Volume

80

Citation

Niehaus Gary D; Ervin Elyce; Patel Amit; Khanna Kamal; Vanek Vincent W; Fagan Diana L, “Circadian variation in cell-adhesion molecule expression by normal human leukocytes.,” NEOMED Bibliography Database, accessed April 15, 2021, https://neomed.omeka.net/items/show/4560.

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