Temporal changes in left ventricular function after massive sympathetic nervous system activation.

Temporal changes in left ventricular function after massive sympathetic nervous system activation.

Lang S A; Maron M B; Bosso F J; Pilati C F

Canadian journal of physiology and pharmacology

1994

1994-06

Intense activation of the sympathetic nervous system (SNS) decreases the contractile state of the rabbit left ventricle (LV). In this study, we determined the time course of LV dysfunction after massive central activation of the SNS in dogs. Veratrine (40-80 micrograms/kg) was injected intracisternally to activate the SNS in six chloralose-anesthetized dogs, and LV end-diastolic pressure (LVEDP), cardiac output, heart rate, and aortic pressure (Pa) were measured at

Acidosis/physiopathology; Anesthesia; Animals; Blood Pressure/physiology; Cardiac Output/physiology; Catecholamines/blood; Dogs; Electron; Female; Heart Rate/physiology; Heart Ventricles/anatomy & histology/ultrastructure; Hypertension/physiopathology; Left/*physiology; Male; Microscopy; Sympathetic Nervous System/drug effects/*physiology; Ventricular Function; Veratrine/pharmacology

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

693–700

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