The JCR:LA-cp rat: a novel rodent model of cystic medial necrosis.

Title

The JCR:LA-cp rat: a novel rodent model of cystic medial necrosis.

Creator

Pung Yuh Fen; Chilian William M; Bennett Martin R; Figg Nichola; Kamarulzaman Mohd Hamzah

Publisher

American journal of physiology. Heart and circulatory physiology

Date

2017
2017-03

Description

Although there are multiple rodent models of the metabolic syndrome, very few develop vascular complications. In contrast, the JCR:LA-cp rat develops both metabolic syndrome and early atherosclerosis in predisposed areas. However, the pathology of the normal vessel wall has not been described. We examined JCR:LA control (+/+) or cp/cp rats fed normal chow diet for 6 or 18 mo. JCR:LA-cp rats developed multiple features of advanced cystic medial necrosis including "cysts," increased collagen formation and proteoglycan deposition around cysts, apoptosis of vascular smooth muscle cells, and spotty medial calcification. These appearances began within 6 mo and were extensive by 18 mo. JCR:LA-cp rats had reduced medial cellularity, increased medial thickness, and vessel hypoxia that was most marked in the adventitia. In conclusion, the normal chow-fed JCR:LA-cp rat represents a novel rodent model of cystic medial necrosis, associated with multiple metabolic abnormalities, vascular smooth muscle cell apoptosis, and vessel hypoxia.NEW & NOTEWORTHY Triggers for cystic medial necrosis (CMN) have been difficult to study due to lack of animal models to recapitulate the pathologies seen in humans. Our study is the first description of CMN in the rat. Thus the JCR:LA-cp rat represents a useful model to investigate the underlying molecular changes leading to the development of CMN.

Subject

*Rats; Animal; Animals; Aortic Aneurysm; Atherosclerosis/pathology; Blood Glucose/metabolism; Blood Vessels/pathology; Body Weight; Collagen/biosynthesis; Cysts/*genetics/pathology; Disease Models; hypoxia; Hypoxia; Inbred Strains; leptin; Lipids/blood; Male; metabolic syndrome; Metabolic Syndrome/*genetics/pathology; Necrosis; Proteoglycans/biosynthesis; Rats; rodent model; Thoracic/*genetics/pathology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

H541–H545

Issue

3

Volume

312

Citation

Pung Yuh Fen; Chilian William M; Bennett Martin R; Figg Nichola; Kamarulzaman Mohd Hamzah, “The JCR:LA-cp rat: a novel rodent model of cystic medial necrosis.,” NEOMED Bibliography Database, accessed October 25, 2021, https://neomed.omeka.net/items/show/4603.

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