Inhibition of cardiac fibroblast proliferation and myofibroblast differentiation by resveratrol.

Title

Inhibition of cardiac fibroblast proliferation and myofibroblast differentiation by resveratrol.

Creator

Olson Erik R; Naugle Jennifer E; Zhang Xiaojin; Bomser Joshua A; Meszaros J Gary

Publisher

American journal of physiology. Heart and circulatory physiology

Date

2005
2005-03

Description

Cardiac fibroblasts (CFs) regulate myocardial remodeling by proliferating, differentiating, and secreting extracellular matrix proteins. Prolonged activation of CFs leads to cardiac fibrosis and reduced myocardial contractile function. Resveratrol (RES) exhibits a number of cardioprotective properties; however, the possibility that this compound affects CF function has not been considered. The current study tests whether RES directly influences the growth and proliferation of CFs and differentiation to the hypersecretory myofibroblast phenotype. Pretreatment of CFs with RES (5-25 microM) inhibited basal and ANG

Subject

70-kDa/metabolism; Angiotensin II/pharmacology; Animals; Antioxidants/*pharmacology; Cell Differentiation/drug effects; Cell Division/drug effects; Cells; Cultured; Drug Interactions; Epidermal Growth Factor/pharmacology; Fibroblasts/*cytology/*drug effects; Male; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Myocardium/*cytology; Protein-Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins/metabolism; Rats; Resveratrol; Ribosomal Protein S6 Kinases; Signal Transduction/drug effects; Sprague-Dawley; Stilbenes/*pharmacology; Vasoconstrictor Agents/pharmacology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

H1131–1138

Issue

3

Volume

288

Citation

Olson Erik R; Naugle Jennifer E; Zhang Xiaojin; Bomser Joshua A; Meszaros J Gary, “Inhibition of cardiac fibroblast proliferation and myofibroblast differentiation by resveratrol.,” NEOMED Bibliography Database, accessed April 23, 2021, https://neomed.omeka.net/items/show/4604.

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