Inhibition of cardiac fibroblast proliferation and myofibroblast differentiation by resveratrol.

Inhibition of cardiac fibroblast proliferation and myofibroblast differentiation by resveratrol.

Olson Erik R; Naugle Jennifer E; Zhang Xiaojin; Bomser Joshua A; Meszaros J Gary

American journal of physiology. Heart and circulatory physiology

2005

2005-03

Cardiac fibroblasts (CFs) regulate myocardial remodeling by proliferating, differentiating, and secreting extracellular matrix proteins. Prolonged activation of CFs leads to cardiac fibrosis and reduced myocardial contractile function. Resveratrol (RES) exhibits a number of cardioprotective properties; however, the possibility that this compound affects CF function has not been considered. The current study tests whether RES directly influences the growth and proliferation of CFs and differentiation to the hypersecretory myofibroblast phenotype. Pretreatment of CFs with RES (5-25 microM) inhibited basal and ANG

70-kDa/metabolism; Angiotensin II/pharmacology; Animals; Antioxidants/*pharmacology; Cell Differentiation/drug effects; Cell Division/drug effects; Cells; Cultured; Drug Interactions; Epidermal Growth Factor/pharmacology; Fibroblasts/*cytology/*drug effects; Male; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Myocardium/*cytology; Protein-Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins/metabolism; Rats; Resveratrol; Ribosomal Protein S6 Kinases; Signal Transduction/drug effects; Sprague-Dawley; Stilbenes/*pharmacology; Vasoconstrictor Agents/pharmacology

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H1131–1138

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