IL-1beta-induced cortisol stimulates lung fluid absorption in fetal guinea pigs via SGK-mediated Nedd4-2 inhibition.

IL-1beta-induced cortisol stimulates lung fluid absorption in fetal guinea pigs via SGK-mediated Nedd4-2 inhibition.

Li Tianbo; Koshy Shyny; Folkesson Hans G

American journal of physiology. Lung cellular and molecular physiology

2009

2009-03

We tested the hypothesis that interleukin (IL)-1beta-induced cortisol synthesis stimulates distal lung fluid absorption in fetal guinea pigs via induction of serum- and glucocorticoid-regulated kinase (SGK) and inhibition of neural precursor cell expressed, developmentally downregulated protein 4-2 (Nedd4-2).

Absorption/drug effects; Animals; Base Sequence; Body Fluids/metabolism; DNA/genetics; Endosomal Sorting Complexes Required for Transport; Epithelial Sodium Channels/metabolism; Female; Guinea Pigs; Hydrocortisone/*biosynthesis/blood/physiology; Immediate-Early Proteins/genetics/*metabolism; Interleukin-1beta/*pharmacology; Lung/*drug effects/*physiology; Molecular Sequence Data; Nedd4 Ubiquitin Protein Ligases; Pregnancy; Protein-Serine-Threonine Kinases/genetics/*metabolism; Recombinant Proteins/pharmacology; Ubiquitin-Protein Ligases/*antagonists & inhibitors/genetics

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