Circulating neuropeptide Y does not produce pulmonary hypertension during massive sympathetic activation.

Title

Circulating neuropeptide Y does not produce pulmonary hypertension during massive sympathetic activation.

Creator

Lang S A; Maron M B; Maender K C; Pilati C F

Publisher

Journal of applied physiology (Bethesda, Md. : 1985)

Date

1992
1992-07

Description

We tested the possibility that neuropeptide Y (NPY) may contribute to the pulmonary hypertension that occurs after massive sympathetic activation produced by intracisternal veratrine administration in the chloralose-anesthetized dog. In six dogs, veratrine caused arterial NPY-like immunoreactivity (NPY-LI) to rise from 873 +/- 150 (SE) pg/ml to peak values of 3,780 +/- 666 pg/ml by 60-120 min. (In 3 animals, adrenalectomy significantly reduced the increases in NPY-LI.) In five additional dogs, we infused porcine NPY for 30 min in doses that increased arterial NPY-LI to 8,354 +/- 1,514 pg/ml and observed only minor changes in pulmonary hemodynamics. In three isolated perfused canine left lower lung lobe (LLL) preparations, increasing doses of NPY were administered, producing levels of plasma NPY-LI, at the highest dose, that exceeded those observed after veratrine administration by three orders of magnitude. No changes in LLL arterial or double-occlusion capillary pressures were observed at any dose. Similarly, no changes in LLL hemodynamics were observed in three additional lobes when NPY was administered while norepinephrine was being infused. We conclude that it is unlikely that NPY plays a role as a circulating vasoactive agent in producing the pulmonary hypertension and edema that occur in this model.

Subject

Adrenal Glands/drug effects/physiology; Adrenalectomy; Animals; Dogs; Hypertension; In Vitro Techniques; Neuropeptide Y/*physiology; Norepinephrine/pharmacology; Pulmonary Circulation/drug effects; Pulmonary/chemically induced/*physiopathology; Sympathetic Nervous System/*physiology; Veratrine/pharmacology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

117–122

Issue

1

Volume

73

Citation

Lang S A; Maron M B; Maender K C; Pilati C F, “Circulating neuropeptide Y does not produce pulmonary hypertension during massive sympathetic activation.,” NEOMED Bibliography Database, accessed October 21, 2021, https://neomed.omeka.net/items/show/4646.

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