Effect of neuropeptide Y on hemodynamics of the rabbit lung.

Title

Effect of neuropeptide Y on hemodynamics of the rabbit lung.

Creator

Lang S A; Maron M B

Publisher

Journal of applied physiology (Bethesda, Md. : 1985)

Date

1998
1998-02

Description

We evaluated the effect of neuropeptide Y (NPY) on the hemodynamics of the isolated rabbit lung perfused at constant flow and outflow pressure. Doses of 10(-8) and 10(-7) M NPY increased pulmonary arterial pressure (Ppa) from 11.5 +/- 1.0 (SE) mmHg to, respectively, 16.4 +/- 1.5 and 26.0 +/- 3.8 mmHg (P \textless 0.05, n = 5 mmHg lungs), with 78 +/- 4% of the increase at 10(-7) M resulting from an increased arterial resistance. At the latter dose, pulmonary capillary pressure increased from 5.8 +/- 0.9 to 9.4 +/- 1.0 mmHg (P \textless 0.05). When administered in the presence of norepinephrine, 10(-8) and 10(-7) M NPY (n = 6) produced extreme increases in Ppa to 66.1 +/- 20.5 and 114.7 +/- 25.5 mmHg, respectively, that were due primarily to an increased arterial resistance. To determine the significance of circulating NPY as a pulmonary vasoactive agent, we measured plasma NPY-like immunoreactivity in anesthetized rabbits after massively activating the sympathetic nervous system with veratrine. NPY-like immunoreactivity increased from 74 +/- 10 to 111 +/- 10 (SE) pM (P \textless 0.05). Thus, although NPY is a potent vasoconstrictor in the rabbit lung, it is not likely that plasma NPY concentrations rise sufficiently, even after massive sympathetic nervous system activation, to produce pulmonary vasoconstriction in the intact rabbit.

Subject

Animals; Cisterna Magna; Hemodynamics/*physiology; In Vitro Techniques; Injections; Neuropeptide Y/blood/pharmacology/*physiology; Norepinephrine/pharmacology; Perfusion; Pulmonary Circulation/drug effects/*physiology; Rabbits; Sympathetic Nervous System/drug effects/physiology; Vascular Resistance/drug effects/physiology; Vasoconstriction/drug effects/physiology; Vasoconstrictor Agents/pharmacology; Veratrine/administration & dosage/pharmacology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

618–623

Issue

2

Volume

84

Citation

Lang S A; Maron M B, “Effect of neuropeptide Y on hemodynamics of the rabbit lung.,” NEOMED Bibliography Database, accessed December 9, 2021, https://neomed.omeka.net/items/show/4657.

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