Responses in the inferior colliculus of the guinea pig to concurrent harmonic series and the effect of inactivation of descending controls.

Title

Responses in the inferior colliculus of the guinea pig to concurrent harmonic series and the effect of inactivation of descending controls.

Creator

Nakamoto Kyle T; Shackleton Trevor M; Palmer Alan R

Publisher

Journal of neurophysiology

Date

2010
2010-04

Description

One of the fundamental questions of auditory research is how sounds are segregated because, in natural environments, multiple sounds tend to occur at the same time. Concurrent sounds, such as two talkers, physically add together and arrive at the ear as a single input sound wave. The auditory system easily segregates this input into a coherent perception of each of the multiple sources. A common feature of speech and communication calls is their harmonic structure and in this report we used two harmonic complexes to study the role of the corticofugal pathway in the processing of concurrent sounds. We demonstrate that, in the inferior colliculus (IC) of the anesthetized guinea pig, deactivation of the auditory cortex altered the temporal and/or the spike response to the concurrent, monaural harmonic complexes. More specifically, deactivating the auditory cortex altered the representation of the relative level of the complexes. This suggests that the auditory cortex modulates the representation of the level of two harmonic complexes in the IC. Since sound level is a cue used in the segregation of auditory input, the corticofugal pathway may play a role in this segregation.

Subject

*Acoustic Stimulation; Action Potentials/physiology; Animal; Animals; Auditory Cortex/*physiology; Auditory Pathways/*physiology; Female; Guinea Pigs; Inferior Colliculi/*physiology; Male; Models; Pitch Perception/physiology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

2050–2061

Issue

4

Volume

103

Citation

Nakamoto Kyle T; Shackleton Trevor M; Palmer Alan R, “Responses in the inferior colliculus of the guinea pig to concurrent harmonic series and the effect of inactivation of descending controls.,” NEOMED Bibliography Database, accessed June 13, 2021, https://neomed.omeka.net/items/show/4670.

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