A function for binaural integration in auditory grouping and segregation in the inferior colliculus.

Title

A function for binaural integration in auditory grouping and segregation in the inferior colliculus.

Creator

Nakamoto Kyle T; Shackleton Trevor M; Magezi David A; Palmer Alan R

Publisher

Journal of neurophysiology

Date

2015
2015-03

Description

Responses of neurons to binaural, harmonic complex stimuli in urethane-anesthetized guinea pig inferior colliculus (IC) are reported. To assess the binaural integration of harmonicity cues for sound segregation and grouping, responses were measured to harmonic complexes with different fundamental frequencies presented to each ear. Simultaneously gated harmonic stimuli with fundamental frequencies of 125 Hz and 145 Hz were presented to the left and right ears, respectively, and recordings made from 96 neurons with characteristic frequencies \textgreater2 kHz in the central nucleus of the IC. Of these units, 70 responded continuously throughout the stimulus and were excited by the stimulus at the contralateral ear. The stimulus at the ipsilateral ear excited (EE: 14%; 10/70), inhibited (EI: 33%; 23/70), or had no significant effect (EO: 53%; 37/70), defined by the effect on firing rate. The neurons phase locked to the temporal envelope at each ear to varying degrees depending on signal level. Many of the cells (predominantly EO) were dominated by the response to the contralateral stimulus. Another group (predominantly EI) synchronized to the contralateral stimulus and were suppressed by the ipsilateral stimulus in a phasic manner. A third group synchronized to the stimuli at both ears (predominantly EE). Finally, a group only responded when the waveform peaks from each ear coincided. We conclude that these groups of neurons represent different "streams" of information but exhibit modifications of the response rather than encoding a feature of the stimulus, like pitch.

Subject

*Auditory Perception; Animals; Auditory; binaural integration; Evoked Potentials; Female; Guinea Pigs; harmonic complex; Inferior Colliculi/cytology/*physiology; inferior colliculus; Male; Neurons/physiology; pitch

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1819–1830

Issue

6

Volume

113

Citation

Nakamoto Kyle T; Shackleton Trevor M; Magezi David A; Palmer Alan R, “A function for binaural integration in auditory grouping and segregation in the inferior colliculus.,” NEOMED Bibliography Database, accessed June 13, 2021, https://neomed.omeka.net/items/show/4671.

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