Regulation of bile acid and cholesterol metabolism by PPARs.

Title

Regulation of bile acid and cholesterol metabolism by PPARs.

Creator

Li Tiangang; Chiang John Y L

Publisher

PPAR research

Date

2009
1905-7

Description

Bile acids are amphipathic molecules synthesized from cholesterol in the liver. Bile acid synthesis is a major pathway for hepatic cholesterol catabolism. Bile acid synthesis generates bile flow which is important for biliary secretion of free cholesterol, endogenous metabolites, and xenobiotics. Bile acids are biological detergents that facilitate intestinal absorption of lipids and fat-soluble vitamins. Recent studies suggest that bile acids are important metabolic regulators of lipid, glucose, and energy homeostasis. Agonists of peroxisome proliferator-activated receptors (PPARalpha, PPARgamma, PPARdelta) regulate lipoprotein metabolism, fatty acid oxidation, glucose homeostasis and inflammation, and therefore are used as anti-diabetic drugs for treatment of dyslipidemia and insulin insistence. Recent studies have shown that activation of PPARalpha alters bile acid synthesis, conjugation, and transport, and also cholesterol synthesis, absorption and reverse cholesterol transport. This review will focus on the roles of PPARs in the regulation of pathways in bile acid and cholesterol homeostasis, and the therapeutic implications of using PPAR agonists for the treatment of metabolic syndrome.

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

501739–501739

Volume

2009

Citation

Li Tiangang; Chiang John Y L, “Regulation of bile acid and cholesterol metabolism by PPARs.,” NEOMED Bibliography Database, accessed May 16, 2022, https://neomed.omeka.net/items/show/4689.

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