Brain metastasis in bone and soft tissue cancers: a review of incidence, interventions, and outcomes.

Title

Brain metastasis in bone and soft tissue cancers: a review of incidence, interventions, and outcomes.

Creator

Shweikeh Faris; Bukavina Laura; Saeed Kashif; Sarkis Reem; Suneja Aarushi; Sweiss Fadi; Drazin Doniel

Publisher

Sarcoma

Date

2014
1905-07

Description

Bone and soft tissue malignancies account for a small portion of brain metastases. In this review, we characterize their incidence, treatments, and prognosis. Most of the data in the literature is based on case reports and small case series. Less than 5% of brain metastases are from bone and soft tissue sarcomas, occurring most commonly in Ewing's sarcoma, malignant fibrous tumors, and osteosarcoma. Mean interval from initial cancer diagnosis to brain metastasis is in the range of 20-30 months, with most being detected before 24 months (osteosarcoma, Ewing sarcoma, chordoma, angiosarcoma, and rhabdomyosarcoma), some at 24-36 months (malignant fibrous tumors, malignant peripheral nerve sheath tumors, and alveolar soft part sarcoma), and a few after 36 months (chondrosarcoma and liposarcoma). Overall mean survival ranges between 7 and 16 months, with the majority surviving \textless 12 months (Ewing's sarcoma, liposarcoma, malignant fibrous tumors, malignant peripheral nerve sheath tumors, angiosarcoma and chordomas). Management is heterogeneous involving surgery, radiosurgery, radiotherapy, and chemotherapy. While a survival advantage may exist for those given aggressive treatment involving surgical resection, such patients tended to have a favorable preoperative performance status and minimal systemic disease.

Subject

Bone Neoplasms – Complications; Brain Neoplasms – Epidemiology; Descriptive Statistics; Human; Incidence; Neoplasm Metastasis – Epidemiology; PubMed; Soft Tissue Neoplasms – Complications; Systematic Review; Therapeutics; Treatment Outcomes

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

475175–475175

Volume

2014

Citation

Shweikeh Faris; Bukavina Laura; Saeed Kashif; Sarkis Reem; Suneja Aarushi; Sweiss Fadi; Drazin Doniel, “Brain metastasis in bone and soft tissue cancers: a review of incidence, interventions, and outcomes.,” NEOMED Bibliography Database, accessed October 27, 2021, https://neomed.omeka.net/items/show/4698.

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