Evidence of Oropharyngeal Dysfunction in Feeding in the Rat Rotenone Model of Parkinson's Disease.

Evidence of Oropharyngeal Dysfunction in Feeding in the Rat Rotenone Model of Parkinson's Disease.

Gould Francois D H; Gross Andrew; German Rebecca Z; Richardson Jason R

Parkinson's disease

2018

1905-07

Swallowing disorders in Parkinson's disease are not responsive to dopamine depletion therapy and contribute to morbidity. They are poorly understood owing to a lack of adequate models. We present the first evidence of oropharyngeal changes in a rotenone toxicity model of Parkinson's disease. Rats were recorded while feeding before and after daily rotenone injections at two different doses (2.75 mg/kg and 3 mg/kg). The higher dose had a much more severe parkinsonian phenotype than the low dose. Timing and amplitude of chewing changed, as did the coordination of chewing and swallowing. Dose-dependent effects were evident. These preliminary results indicate that future research in toxicological models of Parkinson's disease should incorporate the study of oropharyngeal dysfunction. A better understanding of nongenetic models of Parkinson's disease in feeding may open new avenues for research into the neurological and behavioral bases for swallowing dysfunction in Parkinson's disease.

Animal Studies; Deglutition – Drug Effects; Deglutition Disorders; Eating – Drug Effects; Feeding Methods; Isoflavones – Administration and Dosage; Isoflavones – Pharmacodynamics; Mastication; Oropharynx – Pathology; Parkinson Disease; Phenotype; Rats

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6537072–6537072

2018