Intestinal Farnesoid X Receptor and Takeda G Protein Couple Receptor 5 Signaling in Metabolic Regulation.

Title

Intestinal Farnesoid X Receptor and Takeda G Protein Couple Receptor 5 Signaling in Metabolic Regulation.

Creator

Chiang John Y L; Pathak Preeti; Liu Hailiang; Donepudi Ajay; Ferrell Jessica; Boehme Shannon

Publisher

Digestive diseases (Basel, Switzerland)

Date

2017
2017

Description

Bile acids play a critical role in the regulation of glucose, lipid and energy metabolisms by activating the nuclear bile acid receptor farnesoid X receptor (FXR) and membrane G protein-coupled bile acid receptor-1 (aka takeda G protein couple receptor 5, TGR5) signaling. Paradoxical roles of FXR in the regulation of glucose and lipid metabolism and metabolic disorder have been reported recently. The activation or inhibition of intestinal FXR signaling has been shown to improve insulin and glucose sensitivity and energy metabolism to prevent diabetes, obesity and non-alcoholic fatty liver disease (NAFLD). TGR5 has an anti-inflammatory function in the intestine and stimulates glucagon-like peptide-1 (GLP-1) secretion in the intestine to stimulate insulin secretion from the pancreas. The role of TGR5 in metabolism and metabolic regulation is not clear and warrants further study. FXR and TGR5 are co-expressed in the ileum and colon. These 2 bile acid-activated receptors may cooperate to stimulate GLP-1 secretion and improve hepatic metabolism. FXR and TGR5 dual agonists may have therapeutic potential for treating diabetes and NAFLD.

Subject

*Signal Transduction; Animals; Bile Acids and Salts/biosynthesis/metabolism; Cytoplasmic and Nuclear/*metabolism; G-Protein-Coupled/*metabolism; Humans; Intestinal Mucosa/*metabolism; Liver/metabolism; Receptors

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

241–245

Issue

3

Volume

35

Citation

Chiang John Y L; Pathak Preeti; Liu Hailiang; Donepudi Ajay; Ferrell Jessica; Boehme Shannon, “Intestinal Farnesoid X Receptor and Takeda G Protein Couple Receptor 5 Signaling in Metabolic Regulation.,” NEOMED Bibliography Database, accessed January 23, 2021, https://neomed.omeka.net/items/show/4731.

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