Prolonged Clostridium difficile Infection May Be Associated With Vitamin D Deficiency.

Title

Prolonged Clostridium difficile Infection May Be Associated With Vitamin D Deficiency.

Creator

Wong Ken Koon; Lee Rebecca; Watkins Richard R; Haller Nairmeen A

Publisher

JPEN. Journal of parenteral and enteral nutrition

Date

2016
2016-07

Description

BACKGROUND: Clostridium difficile infection (CDI) is one of the leading causes of hospital-acquired infections, creating a financial burden for the U.S. healthcare system. Reports suggest that vitamin D-deficient CDI patients incur higher healthcare-associated expenses and longer lengths of stay compared to nondeficient counterparts. The objective here was to evaluate the relationship between vitamin D level and CDI recurrence. MATERIALS AND METHODS: A retrospective chart review was conducted for 112 patients with vitamin D level drawn within 3 months of CDI diagnosis. Recurrence, severity of disease, 30-day mortality, and course of CDI were assessed. RESULTS: The vitamin D-deficient group included 56 patients, and the normal group included 56 patients. The mean age of vitamin D-deficient and -sufficient groups was 68 +/- 15.7 and 71 +/- 14.4 years, respectively. The mean 25(OH) D level in the deficient group was 11.7 +/- 4.6 ng/mL, and it was 36.2 +/- 16.2 ng/mL in the normal group. A longer course of diarrhea was apparent in the vitamin D-deficient group compared to the normal group: 6.1 days (95% confidence interval [CI], 4.9-7.2) vs 4.2 days (95% CI, 3.5-4.9; P = .01). Sepsis rate was 24% in vitamin D-deficient group and 13% in normal group (P = .03). There were no differences in CDI recurrence, length of stay, severity of illness, and mortality with respect to vitamin D status. CONCLUSION: There may be an association between course of diarrhea and increased rate of sepsis in vitamin D-deficient CDI patients.

Subject

*adult; *gastroenterology; *immunonutrition; *life cycle; *nutrition; *research and diseases; *sepsis; *vitamins; 80 and over; 80 and Over; Aged; Clostridium Infections – Etiology; Clostridium Infections – Mortality; Clostridium Infections – Physiopathology; Clostridium Infections/*etiology/mortality/physiopathology; Diarrhea – Microbiology; Diarrhea – Physiopathology; Diarrhea/microbiology/physiopathology; Female; Humans; Iatrogenic Disease – Epidemiology; Iatrogenic Disease/epidemiology; Length of Stay; Male; Middle Age; Middle Aged; Nutritional Status; Psychological Tests; Recurrence; Retrospective Design; Retrospective Studies; Sepsis – Epidemiology; Sepsis/epidemiology; Severity of Illness Index; Severity of Illness Indices; Vitamin D; Vitamin D – Blood; Vitamin D Deficiency – Blood; Vitamin D Deficiency – Complications; Vitamin D Deficiency/blood/*complications; Vitamin D/analogs & derivatives/blood

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

682–687

Issue

5

Volume

40

Citation

Wong Ken Koon; Lee Rebecca; Watkins Richard R; Haller Nairmeen A, “Prolonged Clostridium difficile Infection May Be Associated With Vitamin D Deficiency.,” NEOMED Bibliography Database, accessed June 15, 2021, https://neomed.omeka.net/items/show/4794.

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