Cholesterol 7alpha-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis.

Title

Cholesterol 7alpha-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis.

Creator

Liu Hailiang; Pathak Preeti; Boehme Shannon; Chiang John Y L

Publisher

Journal of lipid research

Date

2016
2016-10

Description

Cholesterol 7alpha-hydroxylase (CYP7A1) plays a critical role in control of bile acid and cholesterol homeostasis. Bile acids activate farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) to regulate lipid, glucose, and energy metabolism. However, the role of bile acids in hepatic inflammation and fibrosis remains unclear. In this study, we showed that adenovirus-mediated overexpression of Cyp7a1 ameliorated lipopolysaccharide (LPS)-induced inflammatory cell infiltration and pro-inflammatory cytokine production in WT and

Subject

*bile acid; *Cholesterol 7-alpha-Hydroxylase/genetics/metabolism; *farnesoid X receptor; *Homeostasis; *Liver Cirrhosis/chemically induced/enzymology/genetics/prevention & control; *Liver/enzymology/pathology; *nuclear receptor; *Takeda G protein-coupled receptor 5; Animals; Cholesterol/genetics/*metabolism; G-Protein-Coupled/genetics/metabolism; Hep G2 Cells; Humans; Knockout; Mice; NF-kappa B/genetics/metabolism; Oxidative Stress; Receptors; Tumor Necrosis Factor-alpha/genetics/metabolism

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1831–1844

Issue

10

Volume

57

Citation

Liu Hailiang; Pathak Preeti; Boehme Shannon; Chiang John Y L, “Cholesterol 7alpha-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis.,” NEOMED Bibliography Database, accessed January 25, 2021, https://neomed.omeka.net/items/show/4879.

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