Impact of reirradiation of painful osseous metastases on quality of life and function: a secondary analysis of the NCIC CTG SC.20 randomized trial.

Impact of reirradiation of painful osseous metastases on quality of life and function: a secondary analysis of the NCIC CTG SC.20 randomized trial.

Chow Edward; Meyer Ralph M; Chen Bingshu E; van der Linden Yvette M; Roos Daniel; Hartsell William F; Hoskin Peter; Wu Jackson S Y; Nabid Abdenour; Tissing-Tan Caroline J A; Oei Bing; Babington Scott; Demas William F; Wilson Carolyn F; Wong Rebecca K S; Brundage Michael

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2014

2014-12

PURPOSE: We previously demonstrated that 48% of patients with pain at sites of previously irradiated bone metastases benefit from reirradiation. It is unknown whether alleviating pain also improves patient perception of quality of life (QOL). PATIENTS AND METHODS: We used the database of a randomized trial comparing radiation treatment dose fractionation schedules to evaluate whether response, determined using the International Consensus Endpoint (ICE) and Brief Pain Inventory pain score (BPI-PS), is associated with patient perception of benefit, as measured using the European Organisation for Resesarch and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30) and functional interference scale of the BPI (BPI-FI). Evaluable patients completed baseline and

*Quality of Life; 80 and over; Adult; Aged; Bone Neoplasms/complications/psychology/*radiotherapy/*secondary; Dose Fractionation; Emotions; Female; Health Status; Humans; Male; Mental Health; Middle Aged; Pain Measurement; Pain/diagnosis/etiology/*prevention & control/psychology; Radiation; Retreatment; Surveys and Questionnaires; Time Factors; Treatment Outcome; Young Adult

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

3867–3873

34

32