Recent advances in understanding bile acid homeostasis.

Title

Recent advances in understanding bile acid homeostasis.

Creator

Chiang John Y L

Publisher

F1000Research

Date

2017
1905-07

Description

Bile acids are derived from cholesterol to facilitate intestinal nutrient absorption and biliary secretion of cholesterol. Recent studies have identified bile acids as signaling molecules that activate nuclear farnesoid X receptor (FXR) and membrane G protein-coupled bile acid receptor-1 (Gpbar-1, also known as TGR5) to maintain metabolic homeostasis and protect liver and other tissues and cells from bile acid toxicity. Bile acid homeostasis is regulated by a complex mechanism of feedback and feedforward regulation that is not completely understood. This review will cover recent advances in bile acid signaling and emerging concepts about the classic and alternative bile acid synthesis pathway, bile acid composition and bile acid pool size, and intestinal bile acid signaling and gut microbiome in regulation of bile acid homeostasis.

Subject

Bile acid synthesis; gut microbiota; metabolic regulation

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

2029–2029

Volume

6

Citation

Chiang John Y L, “Recent advances in understanding bile acid homeostasis.,” NEOMED Bibliography Database, accessed June 22, 2021, https://neomed.omeka.net/items/show/4918.

Social Bookmarking