Designing drugs with multi-target activity: the next step in the treatment of neurodegenerative disorders.

Title

Designing drugs with multi-target activity: the next step in the treatment of neurodegenerative disorders.

Creator

Geldenhuys Werner J; Van der Schyf Cornelis J

Publisher

Expert opinion on drug discovery

Date

2013
2013-02

Description

INTRODUCTION: Neurodegenerative diseases have had devastating effects on patients' quality of life. These complex diseases have several pathways that are affected to initiate cell death. Current therapies, designed to address only a single target, fall short in mitigating or preventing disease progression, and disease-modifying drugs are desperately needed. Over the past several years, a new paradigm has emerged which has as a goal the targeting of multiple disease etiological pathways. Such "multi-targeted designed drugs" (MTDD) have shown great promise in preclinical studies as neuroprotective agents, as well as being able to afford symptomatic relief to blunt the day-to-day burden of these illnesses. AREAS COVERED: In this review, the authors evaluate the use of chemical scaffolds that led themselves exquisitely to the development of MTDDs in central nervous system disorders. Some of the examples discussed have also transitioned into the clinic, which underscores the importance of pursuing drug discovery programs within the multifunctional arena. EXPERT OPINION: Currently, very little can be done to slow the progress of neurodegeneration. The multifaceted profile of neurodegeneration necessitates a change in paradigm toward the design of compounds that address several drug targets simultaneously. With successful compounds in clinical trials as well as compounds moving into the clinic, support is growing and the feasibility of this approach is now becoming recognized. This review shows that several small molecule scaffolds can be successfully utilized to design MTDD compounds with good CNS pharmacokinetics.

Subject

Humans; Clinical Trials as Topic; *Drug Design; Central Nervous System Diseases/*drug therapy; Neurodegenerative Diseases/*drug therapy; Neuroprotective Agents/*chemistry/therapeutic use

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

115–129

Issue

2

Volume

8

Citation

Geldenhuys Werner J; Van der Schyf Cornelis J, “Designing drugs with multi-target activity: the next step in the treatment of neurodegenerative disorders.,” NEOMED Bibliography Database, accessed May 7, 2021, https://neomed.omeka.net/items/show/4986.

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