Spectral integration in the inferior colliculus: role of glycinergic inhibition in response facilitation.

Title

Spectral integration in the inferior colliculus: role of glycinergic inhibition in response facilitation.

Creator

Wenstrup J J; Leroy S A

Publisher

The Journal of neuroscience : the official journal of the Society for Neuroscience

Date

2001
2001-02

Description

This study examined the contribution of glycinergic inhibition to the time-sensitive spectral integration performed by neurons in the inferior colliculus of the mustached bat (Pteronotus parnellii). These neurons are sometimes called combination-sensitive because they display facilitatory (or inhibitory) responses to the combination of distinct spectral elements in sonar or social vocalizations. Present in a wide range of vertebrates, their temporally and spectrally selective integration is thought to endow them with the ability to discriminate among social vocalizations or to analyze particular cues concerning sonar targets. The mechanisms that underlie these responses or the sites in the auditory system where they are created are not known. We examined combination-sensitive neurons that are facilitated by the presentation of two different harmonic elements of the bat's sonar call and echo. Responses of 24 single units were recorded before and during local application of strychnine, an antagonist of glycinergic inhibition. For each of the 24 units, strychnine application eliminated or greatly reduced temporally sensitive facilitation. There was no difference in this effect for neurons tuned to frequencies associated with the frequency-modulated or the constant-frequency sonar components. These results are unusual because glycine is considered to be an inhibitory neurotransmitter, but here it appears to be essential for the expression of combination-sensitive facilitation. The findings provide strong evidence that facilitatory combination-sensitive response properties present throughout the mustached bat's auditory midbrain, thalamus, and cortex originate through neural interactions in the inferior colliculus.

Subject

Animals; Acoustic Stimulation/methods; Neural Inhibition/drug effects/*physiology; Chiroptera; Inferior Colliculi/drug effects/*physiology; Wakefulness/physiology; Auditory Pathways/drug effects/physiology; Echolocation/*physiology; Glycine Agents/administration & dosage; Glycine/*metabolism; Iontophoresis; Pitch Perception/drug effects/*physiology; Strychnine/administration & dosage; Electrodes; Animal/physiology; Vocalization; Implanted

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

RC124–RC124

Issue

3

Volume

21

Citation

Wenstrup J J; Leroy S A, “Spectral integration in the inferior colliculus: role of glycinergic inhibition in response facilitation.,” NEOMED Bibliography Database, accessed May 12, 2021, https://neomed.omeka.net/items/show/4998.

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