Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses.

Title

Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses.

Creator

Oyewumi Moses O; Kumar Amit; Cui Zhengrong

Publisher

Expert review of vaccines

Date

2010
2010-09

Description

The development of novel immune adjuvants is emerging as a significant area of vaccine delivery based on the continued necessity to amplify immune responses to a wide array of new antigens that are poorly immunogenic. This article specifically focuses on the application of nanoparticles and microparticles as vaccine adjuvants. Many investigators are in agreement that the size of the particles is crucial to their adjuvant activities. However, reports on correlating the size of particle-based adjuvants and the resultant immune responses have been conflicting, with investigators on both sides of the fence with impressive data in support of the effectiveness of particles with small sizes (submicron) over those with larger sizes (micron) and vice versa, while other investigators reported data that showed submicron- and micron-sized particles are effective to the same degree as immune adjuvants. We have generated a list of biological, immunological and, more importantly, vaccine formulation parameters that may have contributed to the inconsistency from different studies and made recommendations on future studies attempting to correlate the size of particulate adjuvants and the immune responses induced. The information gathered could lead to strategies to optimize the performance of nano-microparticles as immune adjuvants.

Subject

Humans; Animals; Immunity; Adaptive Immunity; *Nanoparticles; Particle Size; *Microspheres; Vaccines/*immunology; Innate; Adjuvants; Immunologic/*pharmacology

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1095–1107

Issue

9

Volume

9

Citation

Oyewumi Moses O; Kumar Amit; Cui Zhengrong, “Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses.,” NEOMED Bibliography Database, accessed September 27, 2021, https://neomed.omeka.net/items/show/5021.

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