Natural products of dietary origin as lead compounds in virtual screening and drug design.

Title

Natural products of dietary origin as lead compounds in virtual screening and drug design.

Creator

Geldenhuys Werner J; Bishayee Anupam; Darvesh Altaf S; Carroll Richard T

Publisher

Current pharmaceutical biotechnology

Date

2012
2012-01

Description

Natural products have been found to be useful in the treatment of several diseases across the ages. In this article, we review the use of natural products, obtained from dietary sources, as lead compounds in developing novel therapeutic agents. These compounds have shown tremendous promise in the prevention and as well as treatment of a variety of chronic ailments. In addition, to being patentable and biocompatible, these compounds are a rich source of novel scaffolds to invigorate the pipelines of the pharmaceutical industry. In this communication, we also focus on studies which show how natural products have proved useful as lead compounds in virtual screening and structure-based drug design programs. Natural dietary constituents, such as resveratrol, curcumin and caffeine as well as other compounds, are discussed to illustrate this approach.

Subject

Humans; Animals; Diet; Resveratrol; *Drug Design; *Biological Products/pharmacology; Caffeine/pharmacology; Curcumin/pharmacology; Genistein/pharmacology; Stilbenes/pharmacology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

117–124

Issue

1

Volume

13

Citation

Geldenhuys Werner J; Bishayee Anupam; Darvesh Altaf S; Carroll Richard T, “Natural products of dietary origin as lead compounds in virtual screening and drug design.,” NEOMED Bibliography Database, accessed September 24, 2021, https://neomed.omeka.net/items/show/5068.

Social Bookmarking