A fixed-dose combination of adapalene 0.1%-BPO 2.5% allows an early and sustained improvement in quality of life and patient treatment satisfaction in severe acne.
Title
A fixed-dose combination of adapalene 0.1%-BPO 2.5% allows an early and sustained improvement in quality of life and patient treatment satisfaction in severe acne.
Creator
Brodell Robert T; Schlosser Bethanee J; Rafal Elyse; Toth Darryl; Tyring Stephen; Wertheimer Albert; Kerrouche Nabil; Bucher Delphine
Publisher
The Journal of dermatological treatment
Date
2012
2012-02
Description
INTRODUCTION: Acne has a significant negative impact on quality of life (QoL): lack of self-confidence, depressive symptoms and suicidal thoughts. The objective was to assess the impact of an initial and continued therapy in severe acne patients through patient-related outcomes (PRO). METHODS: In two sequential double-blind randomized studies, patients received either adapalene 0.1% and benzoyl peroxide 2.5% (A-BPO) or vehicle, associated with doxycycline 100 mg for 12 weeks. Patients having obtained at least a good improvement according to investigator global assessment were re-randomized for a 24-week therapy with
Subject
Adult; Female; Humans; Male; Adolescent; Young Adult; Child; Severity of Illness Index; Quality of Life/*psychology; Double-Blind Method; *Patient Satisfaction; Drug Combinations; Acne Vulgaris/*drug therapy/*psychology; Adapalene; Benzoyl Peroxide/administration & dosage/*therapeutic use; Dermatologic Agents/administration & dosage/*therapeutic use; Naphthalenes/administration & dosage/*therapeutic use
Identifier
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Citation
Brodell Robert T; Schlosser Bethanee J; Rafal Elyse; Toth Darryl; Tyring Stephen; Wertheimer Albert; Kerrouche Nabil; Bucher Delphine, “A fixed-dose combination of adapalene 0.1%-BPO 2.5% allows an early and sustained improvement in quality of life and patient treatment satisfaction in severe acne.,” NEOMED Bibliography Database, accessed January 25, 2025, https://neomed.omeka.net/items/show/5100.