A fixed-dose combination of adapalene 0.1%-BPO 2.5% allows an early and sustained improvement in quality of life and patient treatment satisfaction in severe acne.

Title

A fixed-dose combination of adapalene 0.1%-BPO 2.5% allows an early and sustained improvement in quality of life and patient treatment satisfaction in severe acne.

Creator

Brodell Robert T; Schlosser Bethanee J; Rafal Elyse; Toth Darryl; Tyring Stephen; Wertheimer Albert; Kerrouche Nabil; Bucher Delphine

Publisher

The Journal of dermatological treatment

Date

2012
2012-02

Description

INTRODUCTION: Acne has a significant negative impact on quality of life (QoL): lack of self-confidence, depressive symptoms and suicidal thoughts. The objective was to assess the impact of an initial and continued therapy in severe acne patients through patient-related outcomes (PRO). METHODS: In two sequential double-blind randomized studies, patients received either adapalene 0.1% and benzoyl peroxide 2.5% (A-BPO) or vehicle, associated with doxycycline 100 mg for 12 weeks. Patients having obtained at least a good improvement according to investigator global assessment were re-randomized for a 24-week therapy with

Subject

Adult; Female; Humans; Male; Adolescent; Young Adult; Child; Severity of Illness Index; Quality of Life/*psychology; Double-Blind Method; *Patient Satisfaction; Drug Combinations; Acne Vulgaris/*drug therapy/*psychology; Adapalene; Benzoyl Peroxide/administration & dosage/*therapeutic use; Dermatologic Agents/administration & dosage/*therapeutic use; Naphthalenes/administration & dosage/*therapeutic use

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

26–34

Issue

1

Volume

23

Citation

Brodell Robert T; Schlosser Bethanee J; Rafal Elyse; Toth Darryl; Tyring Stephen; Wertheimer Albert; Kerrouche Nabil; Bucher Delphine, “A fixed-dose combination of adapalene 0.1%-BPO 2.5% allows an early and sustained improvement in quality of life and patient treatment satisfaction in severe acne.,” NEOMED Bibliography Database, accessed May 16, 2021, https://neomed.omeka.net/items/show/5100.

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