Thermoreversible gel for delivery of activin receptor-like kinase 5 inhibitor

Thermoreversible gel for delivery of activin receptor-like kinase 5 inhibitor

Sutariya Vijaykumar; Miladore Nicholas; Geldenhuys Werner; Bhatia Deepak; Wehrung Daniel; Nakamura Hiroshi

Pharmaceutical development and technology

2013

2013-08

The purpose of this study is to investigate a thermoreversible gel using Pluronic

Time Factors; Animals; Body Temperature; *Drug Delivery Systems; Temperature; Rabbits; Benzodioxoles/*administration & dosage/pharmacokinetics/toxicity; Delayed-Action Preparations; Drug Carriers/chemistry/toxicity; Fibroblasts/drug effects/metabolism; Filtering Surgery/*methods; Gels; Glaucoma/*surgery; Imidazoles/*administration & dosage/pharmacokinetics/toxicity; Poloxamer/chemistry/toxicity; Protein-Serine-Threonine Kinases/antagonists & inhibitors; Pyridines/*administration & dosage/pharmacokinetics/toxicity; Viscosity; Receptors; Receptor; Animal; Disease Models; Transforming Growth Factor-beta Type I; Transforming Growth Factor beta/antagonists & inhibitors

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

957–962

4

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