Descending projections from auditory cortex to excitatory and inhibitory cells in the nucleus of the brachium of the inferior colliculus.

Title

Descending projections from auditory cortex to excitatory and inhibitory cells in the nucleus of the brachium of the inferior colliculus.

Creator

Mellott Jeffrey G; Bickford Martha E; Schofield Brett R

Publisher

Frontiers in systems neuroscience

Date

2014
1905-07

Description

Descending projections from the auditory cortex (AC) terminate in subcortical auditory centers from the medial geniculate nucleus (MG) to the cochlear nucleus, allowing the AC to modulate the processing of acoustic information at many levels of the auditory system. The nucleus of the brachium of the inferior colliculus (NBIC) is a large midbrain auditory nucleus that is a target of these descending cortical projections. The NBIC is a source of several auditory projections, including an ascending projection to the MG. This ascending projection appears to originate from both excitatory and inhibitory NBIC cells, but whether the cortical projections contact either of these cell groups is unknown. In this study, we first combined retrograde tracing and immunochemistry for glutamic acid decarboxylase (GAD, a marker of GABAergic cells) to identify GABAergic and non-GABAergic NBIC projections to the MG. Our first result is that

Subject

GABA; ascending; corticofugal; medial geniculate nucleus; modulation

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

188–188

Volume

8

Citation

Mellott Jeffrey G; Bickford Martha E; Schofield Brett R, “Descending projections from auditory cortex to excitatory and inhibitory cells in the nucleus of the brachium of the inferior colliculus.,” NEOMED Bibliography Database, accessed September 25, 2021, https://neomed.omeka.net/items/show/5145.

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