Regulation of aldo-keto reductases in human diseases.

Title

Regulation of aldo-keto reductases in human diseases.

Creator

Chen Wei-Dong; Zhang Yanqiao

Publisher

Frontiers in pharmacology

Date

2012
1905-07

Description

The aldo-keto reductases (AKRs) are a superfamily of NAD(P)H-linked oxidoreductases, which reduce aldehydes and ketones to their respective primary and secondary alcohols. AKR enzymes are increasingly being recognized to play an important role in the transformation and detoxification of aldehydes and ketones generated during drug detoxification and xenobiotic metabolism. Many transcription factors have been identified to regulate the expression of human AKR genes, which could have profound effects on the metabolism of endogenous mediators and detoxication of chemical carcinogens. This review summarizes the current knowledge on AKR regulation by transcription factors and other mediators in human diseases.

Subject

aldo-keto reductase; human disease; regulation; response element; transcription factor

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

35–35

Volume

3

Citation

Chen Wei-Dong; Zhang Yanqiao, “Regulation of aldo-keto reductases in human diseases.,” NEOMED Bibliography Database, accessed February 27, 2021, https://neomed.omeka.net/items/show/5147.

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