Mechanism of Breast Cancer Preventive Action of Pomegranate: Disruption of Estrogen Receptor and Wnt/beta-Catenin Signaling Pathways.
Title
Mechanism of Breast Cancer Preventive Action of Pomegranate: Disruption of Estrogen Receptor and Wnt/beta-Catenin Signaling Pathways.
Creator
Mandal Animesh; Bishayee Anupam
Publisher
Molecules (Basel, Switzerland)
Date
2015
2015-12
Description
A pomegranate emulsion (PE), containing various bioactive phytochemicals, has recently been found to exert substantial chemopreventive effect against 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumorigenesis in rats via antiproliferative and proapoptotic actions. Nevertheless, the underlying mechanisms of action are not completely understood. The present study was designed to investigate the effects of PE treatment on intratumor expression of estrogen receptor (ER)-alpha, ER-beta,beta-catenin and cyclin D1 during DMBA rat mammary carcinogenesis. Mammary tumor sections were harvested from a chemopreventive study in which PE (0.2, 1.0 and 5.0 g/kg) exhibited inhibition of mammary tumorigenesis in a dose-response manner. The expressions of ER-alpha,
Subject
Female; Animals; Cell Proliferation/drug effects; Rats; DMBA; Punicaceae/*chemistry; Down-Regulation/drug effects; Estrogen Receptor alpha/metabolism; Anticarcinogenic Agents/*pharmacology; beta Catenin/*metabolism; beta-catenin; Breast Neoplasms/*drug therapy/metabolism; Chemoprevention/methods; cyclin D1; estrogen receptors; mammary tumorigenesis; pomegranate (Punica granatum L.); Wnt Proteins/*metabolism; Wnt Signaling Pathway/*drug effects; Sprague-Dawley; Receptors; 10-Dimethyl-1; 9; Cell Transformation; 2-benzanthracene/pharmacology; Estrogen/*metabolism; Neoplastic/drug effects/metabolism
Identifier
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Citation
Mandal Animesh; Bishayee Anupam, “Mechanism of Breast Cancer Preventive Action of Pomegranate: Disruption of Estrogen Receptor and Wnt/beta-Catenin Signaling Pathways.,” NEOMED Bibliography Database, accessed April 25, 2024, https://neomed.omeka.net/items/show/5154.