Mechanism of Breast Cancer Preventive Action of Pomegranate: Disruption of Estrogen Receptor and Wnt/beta-Catenin Signaling Pathways.

Title

Mechanism of Breast Cancer Preventive Action of Pomegranate: Disruption of Estrogen Receptor and Wnt/beta-Catenin Signaling Pathways.

Creator

Mandal Animesh; Bishayee Anupam

Publisher

Molecules (Basel, Switzerland)

Date

2015
2015-12

Description

A pomegranate emulsion (PE), containing various bioactive phytochemicals, has recently been found to exert substantial chemopreventive effect against 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumorigenesis in rats via antiproliferative and proapoptotic actions. Nevertheless, the underlying mechanisms of action are not completely understood. The present study was designed to investigate the effects of PE treatment on intratumor expression of estrogen receptor (ER)-alpha, ER-beta,beta-catenin and cyclin D1 during DMBA rat mammary carcinogenesis. Mammary tumor sections were harvested from a chemopreventive study in which PE (0.2, 1.0 and 5.0 g/kg) exhibited inhibition of mammary tumorigenesis in a dose-response manner. The expressions of ER-alpha,

Subject

Female; Animals; Cell Proliferation/drug effects; Rats; DMBA; Punicaceae/*chemistry; Down-Regulation/drug effects; Estrogen Receptor alpha/metabolism; Anticarcinogenic Agents/*pharmacology; beta Catenin/*metabolism; beta-catenin; Breast Neoplasms/*drug therapy/metabolism; Chemoprevention/methods; cyclin D1; estrogen receptors; mammary tumorigenesis; pomegranate (Punica granatum L.); Wnt Proteins/*metabolism; Wnt Signaling Pathway/*drug effects; Sprague-Dawley; Receptors; 10-Dimethyl-1; 9; Cell Transformation; 2-benzanthracene/pharmacology; Estrogen/*metabolism; Neoplastic/drug effects/metabolism

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

22315–22328

Issue

12

Volume

20

Citation

Mandal Animesh; Bishayee Anupam, “Mechanism of Breast Cancer Preventive Action of Pomegranate: Disruption of Estrogen Receptor and Wnt/beta-Catenin Signaling Pathways.,” NEOMED Bibliography Database, accessed December 8, 2021, https://neomed.omeka.net/items/show/5154.

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