Associations between biomarkers of joint metabolism, hand osteoarthritis, and hand pain and function: the Johnston County Osteoarthritis Project.

Associations between biomarkers of joint metabolism, hand osteoarthritis, and hand pain and function: the Johnston County Osteoarthritis Project.

Aslam Imran; Perjar Irina; Shi Xiaoyan A; Renner Jordan B; Kraus Virginia B; Golightly Yvonne M; Jordan Joanne M; Nelson Amanda E

The Journal of rheumatology

2014

2014-05

OBJECTIVE: To determine the associations between joint metabolism biomarkers and hand radiographic osteoarthritis [(rOA), based on Kellgren Lawrence (KL) grade \textgreater/= 2], symptoms, and function. METHODS: Cross-sectional data were available for 663 participants (mean age 63 yrs, 63% white, 49% women). Three definitions of hand rOA were considered: (1) a composite measure involving at least 3 hand joints distributed bilaterally with 2 of 3 in the same joint group, including \textgreater/= 1 distal interphalangeal joint, without metacarpophalangeal (MCP) swelling; (2) rOA in at least 1 joint of a group; and (3) number of joints with KL \textgreater/= 2. We assessed hand symptoms and the 15-item Australian Canadian Hand Osteoarthritis Index (AUSCAN; Likert format). We measured serum cartilage oligomeric matrix protein (sCOMP), hyaluronic acid (sHA), carboxy-terminal propeptide of type II collagen, type II collagen degradation product, urinary C-terminal crosslinked telopeptide of type II collagen, and urinary N-terminal crosslinked telopeptide. Linear regression models were performed to assess associations between each biomarker with hand rOA, AUSCAN, and symptoms, adjusting for age, sex, race, current smoking/drinking status, body mass index, and hip and knee rOA. RESULTS: In adjusted analyses, MCP (p \textless 0.0001) and carpometacarpal rOA (p = 0.003), and a higher number of hand joints with rOA (p = 0.009), were associated with higher levels of sHA. Positive associations were seen between AUSCAN and hand symptoms and levels of sCOMP (p

Adult; Female; Humans; Male; Middle Aged; Aged; Cross-Sectional Studies; Severity of Illness Index; Biomarkers/blood; Radiography; Human; Cross Sectional Studies; Middle Age; Arthralgia/*diagnostic imaging/*metabolism/physiopathology; BIOMARKERS; Carpometacarpal Joints/diagnostic imaging/metabolism/physiopathology; Finger Joint/diagnostic imaging/metabolism/physiopathology; HAND JOINTS; Hand Joints/*diagnostic imaging/*metabolism/physiopathology; Metacarpophalangeal Joint/diagnostic imaging/metabolism/physiopathology; OSTEOARTHRITIS; Osteoarthritis/*diagnostic imaging/*metabolism/physiopathology; RADIOGRAPHY; Severity of Illness Indices; Osteoarthritis – Physiopathology; Biological Markers – Blood; Arthralgia – Metabolism; Arthralgia – Physiopathology; Arthralgia – Radiography; Carpometacarpal Joints – Metabolism; Carpometacarpal Joints – Physiopathology; Carpometacarpal Joints – Radiography; Finger Joint – Metabolism; Finger Joint – Physiopathology; Finger Joint – Radiography; Hand Joints – Metabolism; Hand Joints – Physiopathology; Hand Joints – Radiography; Metacarpophalangeal Joint – Metabolism; Metacarpophalangeal Joint – Physiopathology; Metacarpophalangeal Joint – Radiography; Osteoarthritis – Metabolism; Osteoarthritis – Radiography

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