Noncanonical mechanisms to regulate nuclear receptor signaling.

Title

Noncanonical mechanisms to regulate nuclear receptor signaling.

Creator

Sadana Prabodh

Publisher

Future medicinal chemistry

Date

2012
2012-06

Description

Nuclear receptor (NR)-targeted therapies comprise a large class of clinically employed drugs. A number of drugs currently being used against this protein class were designed as structural analogs of the endogenous ligand of these receptors. In recent years, there has been significant interest in developing newer strategies to target NRs, especially those that rely on mechanistic pathways of NR function. Prominent among these are noncanonical means of targeting NRs, which include selective NR modulation, NR coactivator interaction inhibition, inhibition of NR DNA binding, modulation of NR cellular localization, modulation of NR ligand biosynthesis and downregulation of NR levels in target tissues. This article reviews each of these promising emerging strategies for NR drug development and highlights some of most significant successes achieved in using them.

Subject

Humans; Protein Binding; MicroRNAs/metabolism; Signal Transduction/drug effects; Ligands; DNA/metabolism; Peptides/chemistry/pharmacology; Small Molecule Libraries/chemistry/pharmacology; Receptors; Drug Evaluation; Preclinical; Cytoplasmic and Nuclear/antagonists & inhibitors/*metabolism

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1307–1333

Issue

10

Volume

4

Citation

Sadana Prabodh, “Noncanonical mechanisms to regulate nuclear receptor signaling.,” NEOMED Bibliography Database, accessed September 28, 2021, https://neomed.omeka.net/items/show/5224.

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