A TRP to cardiac fibroblast differentiation.

Title

A TRP to cardiac fibroblast differentiation.

Creator

Thodeti Charles K; Paruchuri Sailaja; Meszaros J Gary

Publisher

Channels (Austin, Tex.)

Date

2013
2013-06

Description

The differentiation of cardiac fibroblasts to myofibroblasts is one of the key events during cardiac remodeling, however, the molecular mechanism underlying this process is not well known. Calcium signaling plays an important role in the regulation of cardiac fibroblast function, but its role in the differentiation of fibroblasts is undefined. Recently four Transient Receptor Potential (TRP) channels TRPM7, TRPC3, TRPC6 and TRPV4 were shown to be crucial for the differentiation of cardiac fibroblasts to myofibroblasts. This addendum sums up the roles described for these four TRP channels in cardiac fibroblast differentiation, and discusses the possible molecular mechanisms underlying this process and its relevance for cardiac remodeling in disease.

Subject

Female; Humans; Male; Animals; TRPV4; *Wound Healing; TRPV Cation Channels/*metabolism; integrin; *Cell Differentiation; cardiac fibroblast; myofibroblast; *Calcium Signaling; *Cell Transdifferentiation; Atrial Fibrillation/*metabolism; differentiation; ECM stiffness; Fibroblasts/*metabolism/*physiology; mechanical signaling; Myofibroblasts/*cytology/*metabolism; Rho/ROCK; TRPC Cation Channels/*metabolism; TRPM Cation Channels/*metabolism; Cellular; *Mechanotransduction

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

211–214

Issue

3

Volume

7

Citation

Thodeti Charles K; Paruchuri Sailaja; Meszaros J Gary, “A TRP to cardiac fibroblast differentiation.,” NEOMED Bibliography Database, accessed March 7, 2021, https://neomed.omeka.net/items/show/5229.

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