Induction of LTP in rat primary visual cortex: tetanus parameters.

Title

Induction of LTP in rat primary visual cortex: tetanus parameters.

Creator

Berry R L; Teyler T J; Han T Z

Publisher

Brain research

Date

1989
1989-03

Description

Long-term potentiation (LTP), intensively studied in the hippocampus as a possible mnemonic device, has begun to be studied in the neocortex. In this study the effects of varying tetanic stimulus parameters on LTP of field potentials recorded from layer II/III induced by white matter stimulation in the in vitro rat visual cortical slice were examined. Low intensity tetanus was more effective in producing LTP than high-intensity tetanus, although single pulses of very high intensity reliably resulted in LTP. LTP consistently occurred following 2 Hz-60 min, or 100 Hz-10 min tetanus; whereas, 10 min of 7 and 25 Hz tetanus usually resulted in long-lasting depression. Although no obvious rule related tetanus frequency and duration to the incidence of LTP, an inverted-U relationship was found between tetanus frequency and LTP magnitude.

Subject

Female; Male; Animals; Rats; Electric Stimulation; In Vitro Techniques; Reaction Time/physiology; Visual Cortex/*physiology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

221–227

Issue

2

Volume

481

Citation

Berry R L; Teyler T J; Han T Z, “Induction of LTP in rat primary visual cortex: tetanus parameters.,” NEOMED Bibliography Database, accessed December 2, 2021, https://neomed.omeka.net/items/show/5311.

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