Cloning and 5'-flanking sequence of a rat cholesterol 7 alpha-hydroxylase gene.

Cloning and 5'-flanking sequence of a rat cholesterol 7 alpha-hydroxylase gene.

Chiang J Y; Yang T P; Wang D P

Biochimica et biophysica acta

1992

1992-10

A cholesterol 7 alpha-hydroxylase gene containing 8 kb of the 5'-flanking region and 5 kb of the transcription region which covers exons 1 to 5 was isolated from a rat genomic library. The 2015 bp nucleotide sequence 5'-upstream from the start codon was determined. This promotor region contains many liver-enriched or -specific elements (TGT3, HNF/LF-B1), putative hormone responsive elements (TRE, GRE, RRE or RARE) and ubiquitous transcription factor binding sites (NF-1,

Animals; Rats; Amino Acid Sequence; Base Sequence; Molecular Sequence Data; Cholesterol 7-alpha-Hydroxylase/*genetics; DNA; Restriction Mapping; Genetic; Cloning; Molecular; *Promoter Regions

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337–339

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