Nuclear receptor regulation of lipid metabolism: potential therapeutics for dyslipidemia, diabetes, and chronic heart and liver diseases.

Title

Nuclear receptor regulation of lipid metabolism: potential therapeutics for dyslipidemia, diabetes, and chronic heart and liver diseases.

Creator

Chiang John Y L

Publisher

Current opinion in investigational drugs (London, England : 2000)

Date

2005
2005-10

Description

Lipids are essential components of biological membranes, fuel molecules and metabolic regulators that control cellular functions, metabolism and homeostasis. The liver plays a central role in regulating lipid metabolism and whole body lipid homeostasis. Sterols, bile acids and fatty acids are the endogenous ligands of the liver orphan receptor, farnesoid X receptor, peroxisome proliferator-activated receptor, vitamin D receptor, constitutive androstane receptor and pregnane X receptor. These metabolic receptors coordinately regulate lipid, glucose, energy and drug metabolism. Alteration of lipid homeostasis causes dyslipidemia, which is a major risk factor contributing to atherosclerotic cardiovascular diseases, diabetes, obesity and liver diseases. Advances in the understanding of the mechanisms of nuclear receptor regulation of lipid homeostasis have provided an opportunity to investigate potential therapeutic drugs targeted to nuclear receptors. This could be useful for the treatment of diabetes, and cardiovascular and chronic liver diseases.

Subject

Humans; Animals; Chronic Disease; *Lipid Metabolism; Hypoglycemic Agents/therapeutic use; Diabetes Mellitus/drug therapy/metabolism; Dyslipidemias/drug therapy/metabolism; Heart Diseases/*drug therapy/metabolism; Hypolipidemic Agents/therapeutic use; Liver Diseases/*drug therapy/metabolism; Metabolic Diseases/*drug therapy/metabolism; Receptors; Cytoplasmic and Nuclear/*metabolism

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

994–1001

Issue

10

Volume

6

Citation

Chiang John Y L, “Nuclear receptor regulation of lipid metabolism: potential therapeutics for dyslipidemia, diabetes, and chronic heart and liver diseases.,” NEOMED Bibliography Database, accessed May 18, 2021, https://neomed.omeka.net/items/show/5347.

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