Analgesic effects of serotonin and receptor-selective serotonin agonists in the rat spinal cord.

Title

Analgesic effects of serotonin and receptor-selective serotonin agonists in the rat spinal cord.

Creator

Crisp T; Stafinsky J L; Spanos L J; Uram M; Perni V C; Donepudi H B

Publisher

General pharmacology

Date

1991
1905-06

Description

1. Serotonin (5-HT) and selective 5-HT receptor agonists were administered intrathecally (i.t.) in rats, and the antinociceptive efficacy of these agents was assessed on the tail-flick and hot plate tests. 2. The 5-HT receptor agonists examined in this study included the 5-HT1A agonist

Subject

Male; Animals; Rats; Pain Measurement; Piperazines/pharmacology; Spinal Cord/*physiology; Tetrahydronaphthalenes/pharmacology; Injections; Amphetamines/pharmacology; Biguanides/pharmacology; Serotonin Antagonists/pharmacology; Reaction Time/drug effects; *Analgesics; 8-Hydroxy-2-(di-n-propylamino)tetralin; Serotonin/*pharmacology; Inbred Strains; Receptors; Spinal; Serotonin/*drug effects/physiology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

247–251

Issue

2

Volume

22

Citation

Crisp T; Stafinsky J L; Spanos L J; Uram M; Perni V C; Donepudi H B, “Analgesic effects of serotonin and receptor-selective serotonin agonists in the rat spinal cord.,” NEOMED Bibliography Database, accessed June 20, 2021, https://neomed.omeka.net/items/show/5357.

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