Analgesic effects of serotonin and receptor-selective serotonin agonists in the rat spinal cord.

Analgesic effects of serotonin and receptor-selective serotonin agonists in the rat spinal cord.

Crisp T; Stafinsky J L; Spanos L J; Uram M; Perni V C; Donepudi H B

General pharmacology

1991

1905-06

1. Serotonin (5-HT) and selective 5-HT receptor agonists were administered intrathecally (i.t.) in rats, and the antinociceptive efficacy of these agents was assessed on the tail-flick and hot plate tests. 2. The 5-HT receptor agonists examined in this study included the 5-HT1A agonist

Male; Animals; Rats; Pain Measurement; Piperazines/pharmacology; Spinal Cord/*physiology; Tetrahydronaphthalenes/pharmacology; Injections; Amphetamines/pharmacology; Biguanides/pharmacology; Serotonin Antagonists/pharmacology; Reaction Time/drug effects; *Analgesics; 8-Hydroxy-2-(di-n-propylamino)tetralin; Serotonin/*pharmacology; Inbred Strains; Receptors; Spinal; Serotonin/*drug effects/physiology

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