Aspartame exposure and in vitro hippocampal slice excitability and plasticity.

Title

Aspartame exposure and in vitro hippocampal slice excitability and plasticity.

Creator

Fountain S B; Hennes S K; Teyler T J

Publisher

Fundamental and applied toxicology : official journal of the Society of Toxicology

Date

1988
1988-08

Description

Aspartame (APM) is a low-calorie sweetener recently approved and released for widespread use in the United States. However, concerns still exist that APM consumption may be responsible for adverse neurological and psychological effects in some people. In addition, recent reports indicate that APM exposure may alter regional brain neurotransmitter levels. The present study assessed the effects of APM and its amino acid moieties on rat hippocampal slice excitability and plasticity. Specifically, tests of excitatory systems, inhibitory systems, and synaptic plasticity (induction of long-term potentiation–LTP) were administered postexposure. Exposures of 0.01, 0.1, 1, and 10 mM APM potentiated the response of hippocampal CA1 pyramidal cells, but had no apparent effect on local inhibitory systems. APM exposure did not block the establishment of LTP at any dose despite the potentiation of pyramidal cell response observed postexposure. In addition, 0.1 mM phenylalanine (PHE) produced a greater increase in excitability than that produced by an equivalent dose of APM, 0.1 mM aspartic acid (ASP) and 0.1 mM phenylalanine methyl ester (PM) produced effects comparable to those produced a smaller, but reliable, change in hippocampal CA1 excitability relative to baseline. Like APM, none of the amino acids produced detectable changes in inhibitory systems or neuronal plasticity.

Subject

Female; Time Factors; Animals; Rats; Electric Stimulation; Electrophysiology; Neurons/drug effects; Aspartame/*toxicity; Dipeptides/*toxicity; Hippocampus/*drug effects/physiopathology; Neuronal Plasticity/*drug effects

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

221–228

Issue

2

Volume

11

Citation

Fountain S B; Hennes S K; Teyler T J, “Aspartame exposure and in vitro hippocampal slice excitability and plasticity.,” NEOMED Bibliography Database, accessed May 6, 2021, https://neomed.omeka.net/items/show/5408.

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