Local blistering reaction complicating subcutaneous injection of pegylated interferon in a patient with hepatitis C.

Local blistering reaction complicating subcutaneous injection of pegylated interferon in a patient with hepatitis C.

Gallina Kelly; Brodell Robert T; Naffah Farid; Nedorost Susan

Journal of drugs in dermatology : JDD

2003

2003-01

PEG-Intron is a covalent conjugate of recombinant alpha-2b interferon with monomethoxy polyethylene glycol (PEG). Compared to standard interferon-alpha injections, this preparation has a longer half-life allowing for once-weekly injections and superior antiviral efficacy in the treatment of hepatitis C when used in combination with ribavirin. We report the first case of a local blistering reaction developing in a patient receiving pegylated interferon-alpha-2b. Previous reports of local cutaneous reactions to standard and pegylated interferon-alpha are reviewed and the pathophysiological mechanisms are discussed.

Humans; Male; Middle Aged; Recombinant Proteins; *Interferon-alpha/*administration & dosage/*adverse effects; *Polyethylene Glycols; Blister/*chemically induced/pathology; Hepatitis C/*drug therapy; Interferon alpha-2; Injections; Subcutaneous

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63–67

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