Local blistering reaction complicating subcutaneous injection of pegylated interferon in a patient with hepatitis C.

Title

Local blistering reaction complicating subcutaneous injection of pegylated interferon in a patient with hepatitis C.

Creator

Gallina Kelly; Brodell Robert T; Naffah Farid; Nedorost Susan

Publisher

Journal of drugs in dermatology : JDD

Date

2003
2003-01

Description

PEG-Intron is a covalent conjugate of recombinant alpha-2b interferon with monomethoxy polyethylene glycol (PEG). Compared to standard interferon-alpha injections, this preparation has a longer half-life allowing for once-weekly injections and superior antiviral efficacy in the treatment of hepatitis C when used in combination with ribavirin. We report the first case of a local blistering reaction developing in a patient receiving pegylated interferon-alpha-2b. Previous reports of local cutaneous reactions to standard and pegylated interferon-alpha are reviewed and the pathophysiological mechanisms are discussed.

Subject

Humans; Male; Middle Aged; Recombinant Proteins; *Interferon-alpha/*administration & dosage/*adverse effects; *Polyethylene Glycols; Blister/*chemically induced/pathology; Hepatitis C/*drug therapy; Interferon alpha-2; Injections; Subcutaneous

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

63–67

Issue

1

Volume

2

Citation

Gallina Kelly; Brodell Robert T; Naffah Farid; Nedorost Susan, “Local blistering reaction complicating subcutaneous injection of pegylated interferon in a patient with hepatitis C.,” NEOMED Bibliography Database, accessed February 25, 2021, https://neomed.omeka.net/items/show/5412.

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