Clonidine in the treatment of premenstrual syndrome: a subgroup study.

Clonidine in the treatment of premenstrual syndrome: a subgroup study.

Giannini A J; Sullivan B; Sarachene J; Loiselle R H

The Journal of clinical psychiatry

1988

1988-02

The authors studied the effects of clonidine on a subgroup of women who had symptoms associated with premenstrual syndrome; the subgroup comprised 24 women aged 19 to 41 years who had "moderate" to "severe" cyclic decreases in beta-endorphin levels. All of the women received clonidine and placebo in a double-blind cross-over design that spanned four menstrual cycles. Clonidine was significantly (p less than .05) more effective than placebo in reducing symptoms.

Adult; Female; Humans; Double-Blind Method; Clinical Trials as Topic; Psychiatric Status Rating Scales; Placebos; beta-Endorphin/blood; Clonidine/*therapeutic use; Premenstrual Syndrome/blood/*drug therapy/psychology

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

62–63

2

49