Antitumor effect of novel silatranes on renal cell carcinoma in mice.

Antitumor effect of novel silatranes on renal cell carcinoma in mice.

Grna A; Koo P H; Hogan J

Anticancer research

1992

1992-04

The effect of several novel silatrane derivatives on the growth of syngeneic renal cell carcinoma (RENCA) in BALB/c mice and the survival rate of the animals were evaluated. The RENCA-bearing animals were treated subcutaneously and weekly with either a water-insoluble or a water-soluble derivative. The silatrane-treated animals were either free of palpable tumors or developed tumors much more slowly in comparison with the control animals without silatranes. The treated animals as a whole also died of tumor at much slower rates. Attempts to use higher silatrane dosages to achieve better curative effects were hampered by the toxicity of these compounds.

Female; Animals; Mice; Structure-Activity Relationship; Antineoplastic Agents/pharmacology/*therapeutic use; Kidney Neoplasms/*drug therapy; *Organosilicon Compounds; Bridged Bicyclo Compounds/pharmacology/*therapeutic use; Silicon/pharmacology/*therapeutic use; Carcinoma; Inbred BALB C; Heterocyclic; *Bridged Bicyclo Compounds; Renal Cell/*drug therapy

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

565–569

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