Tromantadine inhibits a late step in herpes simplex virus type 1 replication and syncytium formation.

Tromantadine inhibits a late step in herpes simplex virus type 1 replication and syncytium formation.

Ickes D E; Venetta T M; Phonphok Y; Rosenthal K S

Antiviral research

1990

1990-08

Addition of tromantadine after virus penetration inhibited HSV-1 induced syncytium formation and virus production in HEp-2 and VERO cells and acted additively with neutralizing antibody in blocking virus spread and cytopathology. Inhibition of syncytium formation in VERO cells infected with 0.01 pfu/cell of

Time Factors; Animals; Rabbits; Fluorescent Antibody Technique; Viral Envelope Proteins/biosynthesis; Virus Replication/*drug effects; Vero Cells; Antibodies; Amantadine/*analogs & derivatives/pharmacology; Cycloheximide/pharmacology; Giant Cells/*drug effects; Glycoproteins/biosynthesis; Membrane Proteins/biosynthesis; Neutralization Tests; Simplexvirus/*drug effects/physiology; Viral/immunology

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