Gallstones induced by sex steroids in the female Syrian hamster: duration effects.

Title

Gallstones induced by sex steroids in the female Syrian hamster: duration effects.

Creator

Karkare S; Gilloteaux J

Publisher

Journal of submicroscopic cytology and pathology

Date

1995
1995-01

Description

Scanning (SEM), and transmission (TEM) electron microscopy were used and correlated to morphologically characterize changes induced in the gallbladder epithelium of female Syrian hamster in response to treatments with estradiol (E) alone, and estradiol with medroxyprogesterone (E + MP). Compared with control (C), the E- and E + MP-treated groups demonstrated alterations in the serum lipid profile as well as significantly decreased body weights. The liver with gallbladder weights, as well as the uterus weights, were significantly increased. Two-month E and E + MP treatment groups exhibited increased number of anionically charged apical granules, and luminal mucoid elements. Contrastingly, the three-month treatment groups demonstrated larger and more gallstone-like deposits as compared to the C and two-month E and E + MP groups. This report presents a comprehensive overview of our previous and current data, including that of other investigators in relation to the various factors and parameters involved in the cholelithiatic process.

Subject

Female; Time Factors; Animals; Body Weight; Lipids/blood; Organ Size; Cricetinae; Mesocricetus; Epithelium/drug effects/ultrastructure; Cholelithiasis/*chemically induced; Estradiol/*toxicity; Gallbladder/*drug effects/pathology; Medroxyprogesterone/*toxicity; Microscopy; Electron

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

53–74

Issue

1

Volume

27

Citation

Karkare S; Gilloteaux J, “Gallstones induced by sex steroids in the female Syrian hamster: duration effects.,” NEOMED Bibliography Database, accessed June 16, 2021, https://neomed.omeka.net/items/show/5475.

Social Bookmarking