Morphological aspects of female Syrian hamster gallbladder induced by one-month sex steroid treatment.

Title

Morphological aspects of female Syrian hamster gallbladder induced by one-month sex steroid treatment.

Creator

Karkare S; Kelly T R; Gilloteaux J

Publisher

Journal of submicroscopic cytology and pathology

Date

1995
1995-01

Description

Light (LM), transmission (TEM), and scanning (SEM) electron microscopy were used to characterize morphological changes induced in the gallbladder epithelium of female Syrian hamsters in response to one-month estradiol alone (E) and estradiol with medroxyprogesterone (E + MP) treatments. TEM data were correlated with the SEM observations. Compared with control (C), E- and E + MP-treated hamsters showed significant decreases in body weight, while the liver and gallbladder, and uterus weights increased. Moreover, E treatment induced some subcellular changes (microvilli, nucleus, mitochondria, RER, glycogen, abundant apical granules). The E + MP treatment appeared to exacerbate these similar changes and, in addition, induced apical excrescences and cell shedding. Both E and E + MP gallbladders showed luminal micelles, cellular debris and crystalliths associated with mucus. Simultaneously, an increased acidification of the mucoid content of the apical granules was noticed.

Subject

Female; Animals; Body Weight; Lipids/blood; Organ Size; Cricetinae; Mesocricetus; Epithelium/drug effects/ultrastructure; Estradiol/*toxicity; Medroxyprogesterone/*toxicity; Gallbladder/*drug effects/metabolism/ultrastructure; Microscopy; Electron; Scanning

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

35–52

Issue

1

Volume

27

Citation

Karkare S; Kelly T R; Gilloteaux J, “Morphological aspects of female Syrian hamster gallbladder induced by one-month sex steroid treatment.,” NEOMED Bibliography Database, accessed November 26, 2021, https://neomed.omeka.net/items/show/5476.

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