Adenosine depresses excitatory but not fast inhibitory synaptic transmission in area CA1 of the rat hippocampus.

Title

Adenosine depresses excitatory but not fast inhibitory synaptic transmission in area CA1 of the rat hippocampus.

Creator

Lambert N A; Teyler T J

Publisher

Neuroscience letters

Date

1991
1991-01

Description

The effects of adenosine on inhibitory synaptic transmission in area CA1 were examined using the rat hippocampal slice preparation and intracellular recording. Adenosine did not change fast inhibitory synaptic potentials (IPSPs) but depressed late IPSPs evoked by direct activation of interneurons in the presence of 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV). Directly activated IPSPs were unchanged by the selective adenosine A1 receptor antagonist 8-cyclopentyltheophylline (CPT), but CPT reversed hyperpolarization and depression of late IPSPs produced by adenosine. These results indicate that adenosine depresses disynaptic IPSPs in area CA1 by decreasing synaptic activation of inhibitory neurons.

Subject

Animals; Rats; In Vitro Techniques; Quinoxalines/pharmacology; 2-Amino-5-phosphonovalerate/pharmacology; Membrane Potentials/drug effects; Hippocampus/drug effects/*physiology; Evoked Potentials/drug effects; Synaptic Transmission/*drug effects; Adenosine/*pharmacology; Synapses/*drug effects; Theophylline/analogs & derivatives/pharmacology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

50–52

Issue

1

Volume

122

Citation

Lambert N A; Teyler T J, “Adenosine depresses excitatory but not fast inhibitory synaptic transmission in area CA1 of the rat hippocampus.,” NEOMED Bibliography Database, accessed October 16, 2021, https://neomed.omeka.net/items/show/5499.

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